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CS-W001157 4
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3-Fluoro-2-methylpyridin-4-amine

  • CAS No. 15931-21-2

  • Cat. No. CS-0196835
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

3-Fluoro-2-methylpyridin-4-amine|CS-0196835

Structure of 15931-21-2

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General Information

  • CAS No. 15931-21-2
  • Cat. No. CS-0196835
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₇FN₂
  • Molecular Weight 126.13
  • Synonym(s) 4-AMino-3-fluoro-2-Methylpyridine
  • SMILES NC1=C(F)C(C)=NC=C1

Description

3-Fluoro-2-methylpyridin-4-amine features a strategically positioned fluorine atom and methyl group on the pyridine ring, enhancing electronic modulation and metabolic stability. This electron-deficient heterocycle serves as a key scaffold in kinase inhibitor design and medicinal chemistry optimization.

Application

3-Fluoro-2-methylpyridin-4-amine serves as a versatile building block in medicinal chemistry, enabling efficient access to pyridine-based scaffolds through standard coupling reactions. Its fluorinated heterocyclic core offers enhanced metabolic stability and favorable pharmacokinetic properties, while the ortho-methyl and amine groups provide orthogonal reactivity for further functionalization. The compound exhibits good bench stability and is compatible with common synthetic transformations, facilitating rapid diversification in drug discovery campaigns.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H319
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   38.91
  • LogP   1.11132
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

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