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H-Cys(Trt)-OtBu.HCl

  • CAS No. 158009-03-1

  • Cat. No. CS-0154858
  • Purity≥95%
  • MDL No.MFCD21363202

*For research and further manufacturing use only, not for direct human use.

H-Cys(Trt)-OtBu.HCl|CS-0154858

Structure of 158009-03-1

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General Information

  • CAS No. 158009-03-1
  • Cat. No. CS-0154858
  • Purity ≥95%
  • MDL No. MFCD21363202
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₂₆H₃₀ClNO₂S
  • Molecular Weight 456.04
  • Synonym(s) tert-butyl S-trityl-L-cysteinate hydrochloride
  • SMILES CC(C)(C)OC(=O)[C@H](CSC(C1=CC=CC=C1)(C2=CC=CC=C2)C3=CC=CC=C3)N.Cl

Description

H-Cys(Trt)-OtBu.HCl features a protected cysteine residue with Trt (trityl) on the thiol and OtBu (tert-butyl ester) on the carboxyl group, enabling stable incorporation into peptide chains. The HCl salt enhances solubility and handling under standard synthetic conditions.

Application

H-Cys(Trt)-OtBu·HCl serves as a robust cysteine derivative for peptide synthesis, offering stable thiol protection via the trityl (Trt) group and orthogonal deprotection under mild acidic conditions. The OtBu ester facilitates efficient coupling in solid-phase workflows, while the HCl salt enhances solubility and handling. Ideal for constructing cysteine-containing peptides with high fidelity and minimal side reactions.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   52.32
  • LogP   5.8025
  • H_Acceptors   4
  • H_Donors   1
  • Rotatable_Bonds   7

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