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CS-W001157 4
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2-Fluorocyclopropanecarboxylic acid

  • CAS No. 156816-78-3

  • Cat. No. CS-W006378
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

2-Fluorocyclopropanecarboxylic acid|CS-W006378

Structure of 156816-78-3

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General Information

  • CAS No. 156816-78-3
  • Cat. No. CS-W006378
  • Purity ≥98%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₅FO₂
  • Molecular Weight 104.08
  • Synonym(s) 2-FLUOROCYCLOPROPANE-1-CARBOXYLIC ACID, MIXTURE OF DIASTEREOMERS
  • SMILES O=C(C1C(F)C1)O

Description

2-Fluorocyclopropanecarboxylic acid features a strained cyclopropane ring bearing a fluorine atom and a carboxylic acid group, enabling unique steric and electronic properties. This configuration imparts enhanced metabolic stability and conformational rigidity, making it valuable for medicinal chemistry applications. The molecule exhibits favorable solubility and handles well under standard bench conditions.

Application

2-Fluorocyclopropanecarboxylic acid serves as a valuable building block in medicinal chemistry, enabling the incorporation of a strained cyclopropane motif with a polar carboxylic acid group. Its enhanced metabolic stability and conformational rigidity facilitate target engagement in bioactive molecule design. The fluorine substituent modulates electronic properties and lipophilicity, while the carboxylic acid enables direct derivatization via amide formation or esterification—key steps in peptide and small-molecule synthesis. Bench-stable and compatible with standard reaction conditions, it supports efficient downstream functionalization in both academic and industrial R&D workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS05,GHS07
Signal Word : Danger
UN#: 3261
Class : 8
Packing Group : Ⅱ
Hazard Statements : H302-H314-H335
Precautionary Statements : P260-P264-P270-P271-P280-P301+P330+P331-P304+P340-P363-P405-P501

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Computational Chemistry Data

  • TPSA   37.3
  • LogP   0.429
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   1

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