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CS-W001157 4
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1-Fluorocyclopentanecarboxylic acid

  • CAS No. 1557370-29-2

  • Cat. No. CS-0054991
  • Purity≥97%
  • MDL No.MFCD26727072

*For research and further manufacturing use only, not for direct human use.

1-Fluorocyclopentanecarboxylic acid|CS-0054991

Structure of 1557370-29-2

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General Information

  • CAS No. 1557370-29-2
  • Cat. No. CS-0054991
  • Purity ≥97%
  • MDL No. MFCD26727072
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₉FO₂
  • Molecular Weight 132.13
  • Synonym(s) None
  • SMILES O=C(C1(F)CCCC1)O

Description

1-Fluorocyclopentanecarboxylic acid features a fluorinated cyclopentane ring that imparts enhanced metabolic stability and lipophilicity, making it valuable for medicinal chemistry applications. The carboxylic acid group enables direct derivatization or salt formation, facilitating incorporation into bioactive molecules. This bench-stable, moisture-tolerant reagent streamlines the synthesis of fluorinated analogs in drug discovery workflows.

Application

1-Fluorocyclopentanecarboxylic acid serves as a valuable building block in medicinal chemistry, enabling the introduction of a fluorinated cyclopentane motif into bioactive molecules. The carboxylic acid functionality facilitates direct derivatization via amide, ester, or acyl chloride formation, while the adjacent fluorine atom provides metabolic stability and modulates electronic properties. Its bench-stable nature and compatibility with standard coupling protocols make it well-suited for use in peptide conjugation, heterocycle synthesis, and the construction of pharmacologically relevant scaffolds.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   37.3
  • LogP   1.3533
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   1

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