Lot numbers can be found on the outside label of a product:
Methyl 2-bromo-5-hydroxybenzoate
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CAS No. 154607-00-8
- Cat. No. CS-B1202
- Purity≥96%
- MDL No.MFCD10566797
*For research and further manufacturing use only, not for direct human use.
Structure of 154607-00-8
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General Information
- CAS No. 154607-00-8
- Cat. No. CS-B1202
- Purity ≥96%
- MDL No. MFCD10566797
- Storage 4°C, protect from light
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₈H₇BrO₃
- Molecular Weight 231.04
- Synonym(s) 2-Bromo-5-hydroxybenzoic acid methyl ester; Methyl 2-bromo-5-hydroxybenzenecarboxylate; Benzoic acid, 2-bromo-5-hydroxy-, methyl ester
- SMILES O=C(OC)C1=CC(O)=CC=C1Br
Description
Methyl 2-bromo-5-hydroxybenzoate features a bromine atom at the ortho position and a hydroxyl group at the para position relative to the ester, creating a uniquely functionalized aromatic scaffold. This combination enables selective derivatization in synthetic routes requiring both electrophilic and nucleophilic handles. The compound exhibits good stability under standard bench conditions and integrates readily into multi-step sequences for bioactive molecule synthesis.
Application
Methyl 2-bromo-5-hydroxybenzoate serves as a versatile building block for functionalized aromatic scaffolds, enabling selective derivatization at the hydroxyl and ester groups. The bromo substituent facilitates palladium-catalyzed cross-coupling reactions, while the ortho-positioned hydroxyl allows for protection or direct transformation into ether or ester linkages. Its bench-stable nature and compatibility with standard synthetic protocols make it well-suited for medicinal chemistry and process development workflows.
Synthesis
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Route1
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In-stock
35450-36-3 - ~69%
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In-stock
154607-00-8
References
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BAYER SCHERING PHARMA AKTIENGESELLSCHAFT; BAeRFACKER, Lars; KAST, Raimund; GRIEBENOW, Nils; MEIER, Heinrich; KOLKHOF, Peter; ALBRECHT-KUePPER, Barbara; NITSCHE, Adam; STASCH, Johannes-Peter; SCHNEIDER, Dirk; TEUSCH, Nicole; RUDOLPH, Joachim; WHELAN, James; BULLOCK, William; PLEASIC-WILLIAMS, Susan Patent: WO2010/20363 A1, 2010 ; Location in patent: Page/Page column 94-95 ;
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Route2
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In-stock
19438-10-9 - ~95%
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In-stock
154607-00-8
References
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BANYU PHARMACEUTICAL CO., LTD. Patent: EP1795527 A1, 2007 ; Location in patent: Page/Page column 90 ; EP 1795527 A1
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Route3
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67-56-1 -
In-stock
22921-68-2 - ~%
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In-stock
154607-00-8
References
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TANABE SEIYAKU CO., LTD. Patent: WO2005/61440 A1, 2005 ; Location in patent: Page/Page column 21; 26-27 ;
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Quality Control
Computational Chemistry Data
- TPSA 46.53
- LogP 1.9413
- H_Acceptors 3
- H_Donors 1
- Rotatable_Bonds 1
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Key Words
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