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CS-W001157 4
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2-Isopropyl-4-(methylaminomethyl)thiazole

  • CAS No. 154212-60-9

  • Cat. No. CS-0021066
  • Purity≥98%
  • MDL No.MFCD06797969

*For research and further manufacturing use only, not for direct human use.

2-Isopropyl-4-(methylaminomethyl)thiazole|CS-0021066

Structure of 154212-60-9

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General Information

  • CAS No. 154212-60-9
  • Cat. No. CS-0021066
  • Purity ≥98%
  • MDL No. MFCD06797969
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₁₄N₂S
  • Molecular Weight 170.28
  • Synonym(s) N-Methyl-1-[2-(1-Methylethyl)-1,3-Thiazol-4-Yl]Methanamine
  • SMILES CC(C1=NC(CNC)=CS1)C

Description

2-Isopropyl-4-(methylaminomethyl)thiazole features a thiazole core with a sterically hindered isopropyl group and a methylaminomethyl substituent, delivering enhanced solubility and metabolic stability. This scaffold integrates readily into bioactive molecule design, particularly in kinase inhibitor development and medicinal chemistry lead optimization.

Application

2-Isopropyl-4-(methylaminomethyl)thiazole serves as a versatile heterocyclic building block in medicinal chemistry, enabling the construction of thiazole-based scaffolds with enhanced solubility and metabolic stability. Its methylaminomethyl side chain facilitates downstream functionalization via alkylation or reductive amination, while the isopropyl group provides steric modulation. The compound exhibits good bench stability and compatibility with standard synthetic protocols, making it well-suited for high-throughput screening campaigns and lead optimization workflows.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   24.92
  • LogP   1.9859
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   3

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