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Structure of 1535-76-8
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4-Amino-2-(trifluoromethyl)phenol features a strategically positioned trifluoromethyl group that enhances electron-withdrawal and metabolic stability, while the ortho-amino functionality enables direct coupling in pharmaceutical intermediates. This bench-stable compound integrates readily into complex heterocycles under mild conditions, offering high functional group tolerance for synthetic applications.
4-Amino-2-(trifluoromethyl)phenol serves as a versatile building block in medicinal chemistry, enabling the synthesis of bioactive heterocycles and pharmaceutical intermediates. Its ortho-amino and trifluoromethyl groups provide complementary reactivity for electrophilic substitution, coupling reactions, and directed metalation. The compound exhibits good bench stability and facilitates efficient functionalization under standard conditions, making it valuable for scaffold diversification in drug discovery programs.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: