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CS-W001157 4
Total: USD 88.00

4-Methoxy-3-(trifluoromethyl)aniline

  • CAS No. 393-15-7

  • Cat. No. CS-W010728
  • Purity≥98%
  • MDL No.MFCD00043460

*For research and further manufacturing use only, not for direct human use.

4-Methoxy-3-(trifluoromethyl)aniline|CS-W010728

Structure of 393-15-7

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General Information

  • CAS No. 393-15-7
  • Cat. No. CS-W010728
  • Purity ≥98%
  • MDL No. MFCD00043460
  • Storage RT, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₈F₃NO
  • Molecular Weight 191.15
  • Synonym(s) 5-Amino-2-methoxybenzotrifluoride
  • SMILES COC1=C(C=C(N)C=C1)C(F)(F)F

Description

4-Methoxy-3-(trifluoromethyl)aniline features a trifluoromethyl group that imparts enhanced electron-withdrawing character and metabolic stability, while the methoxy substituent provides moderate electron-donating effects. This balance enables precise tuning of electronic properties in pharmaceutical intermediates and functional materials. The compound exhibits excellent bench stability and compatibility with diverse synthetic transformations under standard conditions.

Application

4-Methoxy-3-(trifluoromethyl)aniline serves as a versatile building block in medicinal chemistry, enabling the synthesis of bioactive heterocycles and pharmaceutical intermediates. Its electron-donating methoxy group and strongly electron-withdrawing trifluoromethyl moiety create a unique electronic profile that enhances reactivity in coupling reactions and facilitates functionalization at multiple sites. The compound exhibits good bench stability, ease of purification, and compatibility with standard synthetic protocols, making it valuable for process-scale applications and targeted scaffold development.

Safety Information

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GHS Pictogram :
GHS No : GHS06
Signal Word : Danger
UN#: 2811
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H302+H312-H315-H319-H331-H335
Precautionary Statements : P264-P270-P330-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   35.25
  • LogP   2.2962
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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