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CS-W001157 4
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6-(Difluoromethoxy)picolinic acid

  • CAS No. 1522367-81-2

  • Cat. No. CS-0058469
  • Molecule weight189.12
  • Purity≥95%
  • MDL No.MFCD27995886

*For research and further manufacturing use only, not for direct human use.

6-(Difluoromethoxy)picolinic acid|CS-0058469

Structure of 1522367-81-2

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General Information

  • CAS No. 1522367-81-2
  • Cat. No. CS-0058469
  • Purity ≥95%
  • MDL No. MFCD27995886
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₅F₂NO₃
  • Molecular Weight 189.12
  • Synonym(s) 6-(difluoromethoxy)pyridine-2-carboxylic acid
  • SMILES FC(F)OC1=NC(C(O)=O)=CC=C1

Description

6-(Difluoromethoxy)picolinic acid is a fluorinated heterocyclic carboxylic acid featuring a difluoromethoxy group at the 6-position of the picolinic ring. This substitution imparts enhanced metabolic stability and lipophilicity, making it valuable for medicinal chemistry applications. The molecule integrates readily into bioactive scaffolds via amidation or esterification, offering a strategic handle for drug discovery projects requiring improved membrane permeability and target engagement.

Application

6-(Difluoromethoxy)picolinic acid serves as a versatile building block for the synthesis of bioactive heterocycles and pharmaceutical intermediates. Its ortho-carboxylic acid functionality enables direct coupling reactions, while the difluoromethoxy group imparts enhanced metabolic stability and modulates lipophilicity. The compound exhibits excellent bench stability and compatibility with standard amide coupling protocols, facilitating efficient access to targeted scaffolds in medicinal chemistry campaigns.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   59.42
  • LogP   1.3812
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   3

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