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CS-W001157 4
Total: USD 88.00

2-Methoxy-6-picolinic acid

  • CAS No. 26893-73-2

  • Cat. No. CS-D1581
  • Purity≥98%
  • MDL No.MFCD06800962

*For research and further manufacturing use only, not for direct human use.

2-Methoxy-6-picolinic acid|CS-D1581

Structure of 26893-73-2

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General Information

  • CAS No. 26893-73-2
  • Cat. No. CS-D1581
  • Purity ≥98%
  • MDL No. MFCD06800962
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₇NO₃
  • Molecular Weight 153.14
  • Synonym(s) 6-Methoxy-2-pyridinecarboxylic acid; 6-Methoxypicolinic acid; methyl 6-methoxypyridine-2-carboxylate
  • SMILES O=C(C1=NC(OC)=CC=C1)O

Description

2-Methoxy-6-picolinic acid features a strategically positioned methoxy group that enhances solubility and modulates electronic properties, while the pyridine ring provides a rigid, electron-deficient scaffold. This combination enables efficient coupling in synthetic transformations and supports integration into bioactive scaffolds under standard conditions.

Application

2-Methoxy-6-picolinic acid serves as a versatile building block in medicinal chemistry, enabling direct access to substituted pyridine scaffolds via standard functional group manipulations. Its ortho-methoxy and carboxylic acid groups provide orthogonal reactivity for coupling, derivatization, and cyclization processes. The compound exhibits excellent bench stability and facilitates purification through crystallization or standard chromatographic methods, supporting efficient integration into multi-step synthetic sequences.

Synthesis

  • Route1
    • In-stock
      6-Oxo-1,6-dihydropyridine-2-carboxylic acid|CS-W002504
      19621-92-2
    • null|null
      74-88-4
    • ~86%
    • In-stock
      2-Methoxy-6-picolinic acid|CS-D1581
      26893-73-2

    References

    • Bonjouklian, Rosanne; Cohen, Jeffrey Daniel; Gruber, Joseph Michael; Johnson, Douglas Webb; Jungheim, Louis Nickolaus; Kroin, Julian Stanley; Lander, Peter Ambrose; Lin, Ho-Shen; Lohman, Mark Christopher; Muehl, Brian Stephen; Norman, Bryan Hurst; Patel, Vinod Francis; Richett, Michael Enrico; Thrasher, Kenneth Jeff; Vepachedu, Sreenivasarao; White, Wesley Todd; Xie, Yongping; York, Jeremy Schulenburg; Parkhurst, Brandon Lee Patent: US2003/100576 A1, 2003 ; US 20030100576 A1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   59.42
  • LogP   0.7884
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   2

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