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CS-W001157 4
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5-Chloro-6-methoxypicolinic acid

  • CAS No. 1214373-91-7

  • Cat. No. CS-0018873
  • Purity≥95%
  • MDL No.MFCD13185830

*For research and further manufacturing use only, not for direct human use.

5-Chloro-6-methoxypicolinic acid|CS-0018873

Structure of 1214373-91-7

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General Information

  • CAS No. 1214373-91-7
  • Cat. No. CS-0018873
  • Purity ≥95%
  • MDL No. MFCD13185830
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₆ClNO₃
  • Molecular Weight 187.58
  • Synonym(s) 5-Chloro-6-methoxypyridine-2-carboxylic acid
  • SMILES O=C(C1=NC(OC)=C(Cl)C=C1)O

Description

5-Chloro-6-methoxypicolinic acid features a chlorine substituent at the 5-position and a methoxy group at the 6-position of the picolinic acid scaffold. This electron-deficient heterocycle integrates readily into medicinal chemistry scaffolds, offering enhanced metabolic stability and targeted binding affinity in bioactive molecule design.

Application

5-Chloro-6-methoxypicolinic acid serves as a versatile building block for medicinal chemistry and agrochemical synthesis, offering a well-defined ortho-functionalized pyridine core. The carboxylic acid group enables direct amidation or esterification, while the chlorine at C5 provides a site for nucleophilic substitution. The methoxy group at C6 enhances solubility and modulates electronic properties, supporting diverse downstream transformations in standard coupling protocols. Its bench-stable crystalline form facilitates handling and purification.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   59.42
  • LogP   1.4418
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   2

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