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Structure of 1522367-81-2
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6-(Difluoromethoxy)picolinic acid is a fluorinated heterocyclic carboxylic acid featuring a difluoromethoxy group at the 6-position of the picolinic ring. This substitution imparts enhanced metabolic stability and lipophilicity, making it valuable for medicinal chemistry applications. The molecule integrates readily into bioactive scaffolds via amidation or esterification, offering a strategic handle for drug discovery projects requiring improved membrane permeability and target engagement.
6-(Difluoromethoxy)picolinic acid serves as a versatile building block for the synthesis of bioactive heterocycles and pharmaceutical intermediates. Its ortho-carboxylic acid functionality enables direct coupling reactions, while the difluoromethoxy group imparts enhanced metabolic stability and modulates lipophilicity. The compound exhibits excellent bench stability and compatibility with standard amide coupling protocols, facilitating efficient access to targeted scaffolds in medicinal chemistry campaigns.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: