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CS-W001157 4
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3-Iodo-2-methylpyridine

  • CAS No. 15112-62-6

  • Cat. No. CS-0210519
  • Purity≥98%
  • MDL No.MFCD09702485

*For research and further manufacturing use only, not for direct human use.

3-Iodo-2-methylpyridine|CS-0210519

Structure of 15112-62-6

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General Information

  • CAS No. 15112-62-6
  • Cat. No. CS-0210519
  • Purity ≥98%
  • MDL No. MFCD09702485
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₆IN
  • Molecular Weight 219.02
  • Synonym(s) 3-Iodo-2-picoline
  • SMILES CC1=C(C=CC=N1)I

Description

3-Iodo-2-methylpyridine features a sterically hindered iodopyridine core with a methyl group at the ortho position, enhancing regioselectivity in cross-coupling reactions. This bench-stable, moisture-tolerant heterocycle integrates efficiently into C–C and C–heteroatom bond formations, enabling streamlined access to complex pyridyl architectures in medicinal chemistry and materials synthesis.

Application

3-Iodo-2-methylpyridine serves as a versatile building block in medicinal chemistry and catalytic cross-coupling reactions. The iodide group enables reliable Suzuki, Stille, and Negishi couplings, while the adjacent methylpyridine framework provides orthogonal reactivity for further functionalization. Bench-stable and readily purified by distillation or chromatography, it functions effectively in Pd-catalyzed transformations and is widely employed in the synthesis of heterocyclic scaffolds relevant to pharmaceutical development.

Synthesis

  • Route1

    References

    • Chemische Berichte, , vol. 73, p. 78
  • Route2

    References

    • Chemische Berichte, , vol. 73, p. 78

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   12.89
  • LogP   1.99462
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   0

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