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CS-W001157 4
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5-(Bromomethyl)furan-2-carbonitrile

  • CAS No. 148759-25-5

  • Cat. No. CS-0612574
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

5-(Bromomethyl)furan-2-carbonitrile|CS-0612574

Structure of 148759-25-5

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General Information

  • CAS No. 148759-25-5
  • Cat. No. CS-0612574
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₄BrNO
  • Molecular Weight 186.01
  • Synonym(s) 5-(Bromomethyl)-2-furancarbonitrile
  • SMILES N#CC1=CC=C(CBr)O1

Description

5-(Bromomethyl)furan-2-carbonitrile features a reactive bromomethyl group tethered to a furan ring bearing a nitrile moiety. This combination enables site-specific conjugation in synthetic workflows, leveraging the electrophilic bromide for nucleophilic substitution while the electron-withdrawing nitrile stabilizes adjacent intermediates. The molecule exhibits bench-stable handling characteristics and integrates efficiently into complex heterocyclic scaffolds under standard conditions.

Application

5-(Bromomethyl)furan-2-carbonitrile serves as a versatile bifunctional building block for heterocyclic synthesis, enabling efficient construction of furan-based scaffolds in medicinal chemistry. The bromomethyl group facilitates nucleophilic substitution reactions, while the nitrile moiety offers compatibility with standard functional group manipulations. Its bench-stable nature and ease of purification support reliable use in multi-step sequences and scale-up workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 3261
Class : 8
Packing Group : Ⅲ
Hazard Statements : H314
Precautionary Statements : P260-P264-P280-P301+P330+P331-P304+P340-P363-P405-P501

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Computational Chemistry Data

  • TPSA   36.93
  • LogP   2.04618
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   1

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