Tel:

Email:

EN
Cat. No. Size / Unit Price Qty
CS-W001157 4
Total: USD 88.00

2-Fluoro-3-nitropyridine

  • CAS No. 1480-87-1

  • Cat. No. CS-D0967
  • Purity≥97%
  • MDL No.MFCD03095068

*For research and further manufacturing use only, not for direct human use.

2-Fluoro-3-nitropyridine|CS-D0967

Structure of 1480-87-1

Please choose your location and provide accurate information for you
Size Stock
Price Quantity

* Please select Quantity before adding items.

General Information

  • CAS No. 1480-87-1
  • Cat. No. CS-D0967
  • Purity ≥97%
  • MDL No. MFCD03095068
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₃FN₂O₂
  • Molecular Weight 142.09
  • Synonym(s) Pyridine, 2-fluoro-3-nitro-
  • SMILES O=[N+](C1=CC=CN=C1F)[O-]

Description

2-Fluoro-3-nitropyridine features a fluorine atom at the 2-position and a nitro group at the 3-position on the pyridine ring, creating a highly electron-deficient heterocyclic scaffold. This combination enables selective electrophilic substitution and facilitates coupling reactions in medicinal chemistry. The molecule exhibits enhanced reactivity for C–H functionalization and serves as a key intermediate in synthesizing bioactive compounds.

Application

2-Fluoro-3-nitropyridine serves as a versatile building block for the synthesis of functionalized pyridine derivatives, enabling electrophilic substitution and transition-metal-catalyzed coupling reactions. The ortho-fluoro and meta-nitro groups provide complementary reactivity for sequential functionalization, with the nitro group readily reducible to an amine or serving as a directing group in metal-catalyzed transformations. Its bench-stable crystalline form facilitates handling and purification, making it well-suited for iterative synthesis in medicinal chemistry and agrochemical development.

Synthesis

  • Route1

    References

    • Peet, Norton P.; Sunder, Shyam Heterocycles, 1986 , vol. 24, # 11 p. 3213 - 3221
  • Route2

    References

    • Yoneda; Fukuhara Tetrahedron, 1996 , vol. 52, # 1 p. 23 - 36

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

  • TPSA   56.03
  • LogP   1.1289
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   1

Other Classifications

Recently Viewed Products

Leave US a Message
Upload Pictures

Key Words

  • 2-Fluoro-3-nitropyridine sigma2-Fluoro-3-nitropyridine manufacturer2-Fluoro-3-nitropyridine price2-Fluoro-3-nitropyridine structure2-Fluoro-3-nitropyridine SDSbuy 2-Fluoro-3-nitropyridine2-Fluoro-3-nitropyridine supplier2-Fluoro-3-nitropyridine uses2-Fluoro-3-nitropyridine molecular weightprice of 2-Fluoro-3-nitropyridine2-Fluoro-3-nitropyridine chemical name formula of 2-Fluoro-3-nitropyridine
This product is not sold in the region.
Confirm
How to get a Lot Number

Lot numbers can be found on the outside label of a product:

ChemScene Label