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CS-W001157 4
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5-Bromo-2-fluoro-3-nitropyridine

  • CAS No. 886372-98-1

  • Cat. No. CS-W005566
  • Purity≥98%
  • MDL No.MFCD07375020

*For research and further manufacturing use only, not for direct human use.

5-Bromo-2-fluoro-3-nitropyridine|CS-W005566

Structure of 886372-98-1

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General Information

  • CAS No. 886372-98-1
  • Cat. No. CS-W005566
  • Purity ≥98%
  • MDL No. MFCD07375020
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₂BrFN₂O₂
  • Molecular Weight 220.98
  • Synonym(s) 5-BROMO-2-FLUORO-3-NITRO-PYRIDINE
  • SMILES O=[N+](C1=CC(Br)=CN=C1F)[O-]

Description

5-Bromo-2-fluoro-3-nitropyridine features a trifunctional pyridine core with bromo, fluoro, and nitro groups positioned for orthogonal reactivity. This electron-deficient heterocycle enables direct coupling in cross-coupling and nucleophilic substitution reactions. The strategic placement of substituents supports efficient functionalization under mild conditions while maintaining stability during storage and handling.

Application

5-Bromo-2-fluoro-3-nitropyridine serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions due to its complementary halogen reactivity. The nitro group facilitates electrophilic substitution and subsequent reduction to an amine, while the fluorine atom provides orthogonal reactivity for late-stage functionalization. Bench-stable and compatible with standard purification protocols, it functions effectively in the synthesis of heterocyclic scaffolds and API intermediates.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   56.03
  • LogP   1.8914
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   1

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