Fmoc-1,4-trans-achc-oh

Name: Fmoc-1,4-trans-achc-oh
Brand: ChemScene
Availability: InStock
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CAS No. 147900-46-7
Cat. No. CS-0226441
Purity≥98%
MDL No.MFCD01862343

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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Structure of 147900-46-7

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Description

Fmoc-1,4-trans-achc-oh features a sterically defined trans-1,4-aminocyclohexane scaffold conjugated to the fluorenylmethoxy carbonyl (Fmoc) protecting group. This configuration enables efficient incorporation into peptide sequences with minimal conformational strain, delivering enhanced stability and predictable folding behavior in synthetic peptide applications.

Application

Fmoc-1,4-trans-achc-OH serves as a robust building block for peptide synthesis, enabling the incorporation of constrained trans-4-aminocyclohexanecarboxylic acid motifs. Its stability under standard coupling conditions and compatibility with orthogonal deprotection protocols facilitate efficient assembly of peptidomimetics and cyclic peptides. The Fmoc group allows for convenient monitoring of chain elongation, while the rigid trans-cyclohexane scaffold imparts defined conformational preorganization, enhancing structural precision in bioactive molecule design.

General Information

CAS No. 147900-46-7
Cat. No. CS-0226441
Purity ≥98%
MDL No. MFCD01862343
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₂₂H₂₃NO₄
Molecular Weight 365.42
Synonym(s) Fmoc-trans-4-aminocyclohexane-1-carboxylic acid
SMILES OC([C@H](CC1)CC[C@@H]1NC(OCC2C3=CC=CC=C3C4=CC=CC=C42)=O)=O

Computational Chemistry Data

TPSA 75.63
LogP 4.1685
H_Acceptors 3
H_Donors 2
Rotatable_Bonds 4

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

Quality Control

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Other Classifications

Building Blocks Functional Group Fmoc

Building Blocks Functional Group Amine

Building Blocks Functional Group Carboxylic Acid

Building Blocks Skeleton Fatty ring compounds Cyclohexane compounds

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Key Words

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Fmoc-1,4-trans-achc-oh

CAS No. 147900-46-7

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