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CS-W001157 4
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{1-[(tert-Butoxy)carbonyl]-1,2,5,6-tetrahydropyridin-3-yl}boronic acid

  • CAS No. 1451153-83-5

  • Cat. No. CS-0185029
  • Molecule weight227.07
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

{1-[(tert-Butoxy)carbonyl]-1,2,5,6-tetrahydropyridin-3-yl}boronic acid|CS-0185029

Structure of 1451153-83-5

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General Information

  • CAS No. 1451153-83-5
  • Cat. No. CS-0185029
  • Purity ≥98%
  • MDL No. None
  • Storage -20°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₁₈BNO₄
  • Molecular Weight 227.07
  • Synonym(s) None
  • SMILES O=C(N1CCC=C(B(O)O)C1)OC(C)(C)C

Description

This tetrahydropyridylboronic acid features a tert-butoxycarbonyl-protected nitrogen, enabling stable handling and selective deprotection during synthesis. The boronic acid moiety integrates readily into Suzuki-Miyaura couplings, while the electron-rich tetrahydropyridine scaffold enhances reactivity in transition-metal-catalyzed transformations.

Application

{1-[(tert-Butoxy)carbonyl]-1,2,5,6-tetrahydropyridin-3-yl}boronic acid serves as a stable, bench-friendly building block for the synthesis of nitrogen-containing heterocycles and bioactive scaffolds. Its tetrahydropyridine core enables diverse Suzuki-Miyaura coupling reactions with excellent functional group tolerance. The Boc-protected amine facilitates orthogonal manipulation in multi-step sequences, while the boronic acid moiety supports efficient purification and compatibility with standard aqueous workups.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   70
  • LogP   0.5656
  • H_Acceptors   4
  • H_Donors   2
  • Rotatable_Bonds   1

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