6-Chloro-2-(trifluoromethyl)nicotinic acid

Name: 6-Chloro-2-(trifluoromethyl)nicotinic acid
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 261635-83-0
Cat. No. CS-W000652
Molecule weightNone
Purity≥98%
MDL No.MFCD11840271

HazMat Fee +

HazMat Fee

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

The shipment is processed through FedEx Ground under the Limited Quantity option.

Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

6-Chloro-2-(trifluoromethyl)nicotinic acid|CS-W000652

Structure of 261635-83-0

Size

Price

Quantity

* Please select Quantity before adding items.

General Information

CAS No. 261635-83-0
Cat. No. CS-W000652
Purity ≥98%
MDL No. MFCD11840271
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₇H₃ClF₃NO₂
Molecular Weight None
Synonym(s) 6-chloro-2-(trifluoromethyl)pyridine-3-carboxylic acid
SMILES ClC1=NC(C(F)(F)F)=C(C(O)=O)C=C1

Description

6-Chloro-2-(trifluoromethyl)nicotinic acid features a trifluoromethyl group at the 2-position and a chlorine substituent at the 6-position of the nicotinic acid scaffold. This electron-deficient heterocycle serves as a key building block in medicinal chemistry, particularly for developing kinase inhibitors and bioactive compounds requiring enhanced metabolic stability and lipophilic character.

Application

6-Chloro-2-(trifluoromethyl)nicotinic acid serves as a versatile building block in medicinal chemistry, enabling the synthesis of biologically active heterocycles and pharmaceutical intermediates. Its electron-deficient pyridine core facilitates nucleophilic aromatic substitution and palladium-catalyzed coupling reactions. The trifluoromethyl group enhances metabolic stability and membrane permeability, while the chloro substituent provides a reliable handle for further functionalization. This compound exhibits excellent bench stability and compatibility with standard purification methods, making it ideal for scalable synthesis workflows.

Safety Information

Download SDS

GHS Pictogram : N/A	GHS No : N/A
Signal Word : N/A	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : N/A
Precautionary Statements : N/A

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

TPSA 50.19
LogP 2.452
H_Acceptors 2
H_Donors 1
Rotatable_Bonds 1

Other Classifications

Building Blocks Functional Group Chloride

Building Blocks Functional Group Carboxylic Acid

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Key Words

261635-83-0 sigma261635-83-0 manufacturer261635-83-0 price261635-83-0 structure261635-83-0 SDSbuy 261635-83-0261635-83-0 supplier261635-83-0 uses261635-83-0 molecular weightprice of 261635-83-0261635-83-0 chemical name formula of 261635-83-0

Salutation:	*Country or Region:
*Applicant Name:	*Organization Name:
*Email Address:	Quantity:
CAS NO. :	Product Name:
Remarks:
Upload Pictures

CAS.No.		Product Name
Applicant Name *		Email Address *
Phone Number *		Organization Name*
Country or Region*		Quantity*
Remarks:

Product Name:
Cat. No.: .		CAS NO. :
Quantity:

6-Chloro-2-(trifluoromethyl)nicotinic acid

CAS No. 261635-83-0

Recommended Products