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CS-W001157 4
Total: USD 88.00

(2-Chloro-6-(trifluoromethyl)pyridin-4-yl)boronic acid

  • CAS No. 1446486-10-7

  • Cat. No. CS-0094319
  • Purity≥95%
  • MDL No.MFCD13188845

*For research and further manufacturing use only, not for direct human use.

(2-Chloro-6-(trifluoromethyl)pyridin-4-yl)boronic acid|CS-0094319

Structure of 1446486-10-7

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General Information

  • CAS No. 1446486-10-7
  • Cat. No. CS-0094319
  • Purity ≥95%
  • MDL No. MFCD13188845
  • Storage -20°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₄BClF₃NO₂
  • Molecular Weight 225.36
  • Synonym(s) 6-TrifluoroMethyl-2-chloropyridine-4-boronic acid
  • SMILES OB(C1=CC(Cl)=NC(C(F)(F)F)=C1)O

Description

This boronate moiety features a trifluoromethyl group that enhances electron-withdrawing character and stability, while the chlorine substituent enables selective cross-coupling. Designed for efficient Suzuki-Miyaura reactions under standard conditions, it delivers robust performance in constructing complex aryl scaffolds with high functional group tolerance.

Application

(2-Chloro-6-(trifluoromethyl)pyridin-4-yl)boronic acid serves as a versatile building block in Suzuki-Miyaura coupling reactions, enabling efficient construction of biaryl and heteroaryl scaffolds. Its trifluoromethyl group enhances metabolic stability and modulates electronic properties, while the boronic acid functionality offers reliable reactivity with aryl halides under mild conditions. The compound exhibits good bench stability and facilitates straightforward purification, making it well-suited for medicinal chemistry and process development workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   53.35
  • LogP   0.4336
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   1

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