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CS-W001157 4
Total: USD 88.00

(2-(Difluoromethyl)pyridin-4-yl)boronic acid

  • CAS No. 1571135-77-7

  • Cat. No. CS-0163544
  • Purity≥98%
  • MDL No.MFCD26517831

*For research and further manufacturing use only, not for direct human use.

(2-(Difluoromethyl)pyridin-4-yl)boronic acid|CS-0163544

Structure of 1571135-77-7

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General Information

  • CAS No. 1571135-77-7
  • Cat. No. CS-0163544
  • Purity ≥98%
  • MDL No. MFCD26517831
  • Storage -20°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₆BF₂NO₂
  • Molecular Weight 172.93
  • Synonym(s) None
  • SMILES OB(C1=CC(C(F)F)=NC=C1)O

Description

This boronate moiety features a difluoromethylpyridine scaffold, delivering enhanced stability and compatibility in cross-coupling reactions. The electron-deficient pyridine ring enables efficient palladium-catalyzed transformations, while the bench-stable boronic acid functionality simplifies handling and integration into complex molecular architectures.

Application

(2-(Difluoromethyl)pyridin-4-yl)boronic acid serves as a versatile building block in Suzuki-Miyaura cross-coupling reactions, enabling efficient construction of biaryl architectures. The difluoromethyl group imparts enhanced metabolic stability and modulates electronic properties, while the pyridine moiety provides a handle for further functionalization. Bench-stable and compatible with a broad range of reaction conditions, it facilitates the synthesis of complex heterocyclic scaffolds relevant to medicinal chemistry and agrochemical development.

Safety Information

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GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 1759
Class : 8
Packing Group : Ⅲ
Hazard Statements : H315-H318-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362-P405-P501

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Computational Chemistry Data

  • TPSA   53.35
  • LogP   -0.301
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   2

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