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5-Methylpyridazin-3-amine

  • CAS No. 144294-43-9

  • Cat. No. CS-0005499
  • Purity≥97%
  • MDL No.MFCD10698051

*For research and further manufacturing use only, not for direct human use.

5-Methylpyridazin-3-amine|CS-0005499

Structure of 144294-43-9

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General Information

  • CAS No. 144294-43-9
  • Cat. No. CS-0005499
  • Purity ≥97%
  • MDL No. MFCD10698051
  • Storage -20°C, sealed storage, away from moisture and light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₇N₃
  • Molecular Weight 109.13
  • Synonym(s) None
  • SMILES NC1=NN=CC(C)=C1

Description

5-Methylpyridazin-3-amine is a nitrogen-rich heterocyclic scaffold featuring a methyl-substituted pyridazine core and a primary amine at the 3-position. This electron-donating amine group enhances reactivity in coupling processes, while the methyl moiety improves metabolic stability and lipophilicity. The compound serves as a key building block in medicinal chemistry, particularly for kinase inhibitors and targeted therapeutics. Its bench-stable nature facilitates handling under standard conditions.

Application

5-Methylpyridazin-3-amine serves as a versatile heterocyclic building block in medicinal chemistry, enabling efficient access to bioactive scaffolds. Its pyridazinamine core exhibits favorable reactivity in Suzuki-Miyaura and Buchwald-Hartwig couplings, while the methyl group enhances metabolic stability. The compound demonstrates excellent bench stability and compatibility with common protecting group strategies, facilitating straightforward purification and integration into multi-step synthesis workflows.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   51.8
  • LogP   0.36722
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   0

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