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CS-W001157 4
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4-Methylpyridazin-3-amine

  • CAS No. 90568-15-3

  • Cat. No. CS-0054996
  • Purity≥97%
  • MDL No.MFCD08460975

*For research and further manufacturing use only, not for direct human use.

4-Methylpyridazin-3-amine|CS-0054996

Structure of 90568-15-3

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General Information

  • CAS No. 90568-15-3
  • Cat. No. CS-0054996
  • Purity ≥97%
  • MDL No. MFCD08460975
  • Storage -20°C, sealed storage, away from moisture and light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₇N₃
  • Molecular Weight 109.13
  • Synonym(s) 4-methyl-3-Pyridazinamine
  • SMILES CC1=C(N)N=NC=C1

Description

4-Methylpyridazin-3-amine features a pyridazin-3-amine core with a methyl group at the 4-position, conferring enhanced electron density and improved solubility in polar solvents. This scaffold integrates readily into bioactive molecules, serving as a key building block in medicinal chemistry for kinase inhibitors and targeted therapeutics.

Application

4-Methylpyridazin-3-amine serves as a versatile heterocyclic building block in medicinal chemistry, enabling the construction of bioactive scaffolds through palladium-catalyzed cross-coupling and electrophilic substitution reactions. The pyridazin-3-amine core exhibits favorable bench stability, tolerates diverse functional groups, and facilitates rapid diversification via amine-directed derivatization, making it well-suited for high-throughput synthesis campaigns.

Synthesis

  • Route1
    • 3-Hydrazinyl-4-methylpyridazine|CS-0317147
      82426-93-5
    • ~%
    • In-stock
      4-Methylpyridazin-3-amine|CS-0054996
      90568-15-3

    References

    • Journal of Medicinal Chemistry, , vol. 30, # 2 p. 239 - 249
  • Route2
    • 5-Hydroxy-4-methyldihydrofuran-2(3h)-one|CS-0668598
      61892-47-5
    • ~%
    • In-stock
      4-Methylpyridazin-3-amine|CS-0054996
      90568-15-3

    References

    • Journal of Medicinal Chemistry, , vol. 30, # 2 p. 239 - 249
  • Route3

    References

    • Journal of Medicinal Chemistry, , vol. 30, # 2 p. 239 - 249

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   51.8
  • LogP   0.36722
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   0

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