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OTs-PEG1-NHCbz

  • CAS No. 144208-62-8

  • Cat. No. CS-0528838
  • Purity≥97%
  • MDL No.MFCD29059964

*For research and further manufacturing use only, not for direct human use.

OTs-PEG1-NHCbz|CS-0528838

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General Information

  • CAS No. 144208-62-8
  • Cat. No. CS-0528838
  • Purity ≥97%
  • MDL No. MFCD29059964
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₉H₂₃NO₆S
  • Molecular Weight 393.45
  • Synonym(s) None
  • SMILES O=C(NCCOCCOS(=O)(C1=CC=C(C)C=C1)=O)OCC2=CC=CC=C2

Description

OTs-PEG1-NHCbz is a bench-stable, moisture-tolerant linker featuring a sulfonate ester handle and a PEG-1 spacer that connects to a carbamoyl-protected nitrogen heterocycle. This design enables efficient conjugation workflows in bioconjugation and probe synthesis, combining high reactivity with ease of handling under standard conditions.

Application

OTs-PEG1-NHCbz serves as a versatile bifunctional linker for peptide and oligonucleotide conjugation, combining the stability of a tosyl (OTs) leaving group with the solubility and biocompatibility of a PEG1 spacer. The NHCbz (N-carbobenzyloxy) moiety enables selective deprotection under mild hydrogenolysis conditions, facilitating controlled release or further functionalization. This reagent facilitates efficient coupling in solid-phase synthesis and offers excellent handling characteristics, making it well-suited for applications in bioconjugate chemistry and targeted drug delivery systems.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   90.93
  • LogP   2.64332
  • H_Acceptors   6
  • H_Donors   1
  • Rotatable_Bonds   10

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