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CS-W001157 4
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4-Methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazole-5-carboxylic acid

  • CAS No. 144059-86-9

  • Cat. No. CS-0215668
  • Molecule weight287.26
  • Purity≥97%
  • MDL No.MFCD00068105

*For research and further manufacturing use only, not for direct human use.

4-Methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazole-5-carboxylic acid|CS-0215668

Structure of 144059-86-9

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General Information

  • CAS No. 144059-86-9
  • Cat. No. CS-0215668
  • Purity ≥97%
  • MDL No. MFCD00068105
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₂H₈F₃NO₂S
  • Molecular Weight 287.26
  • Synonym(s) None
  • SMILES CC1=C(C(=O)O)SC(=N1)C2=CC=C(C=C2)C(F)(F)F

Synthesis

  • Route1
    • Ethyl 4-methyl-2-(4-(trifluoromethyl)phenyl)thiazole-5-carboxylate|CS-0312636
      175277-03-9
    • ~86%
    • 4-Methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazole-5-carboxylic acid|CS-0215668
      144059-86-9

    References

    • Sierra, Michael L.; Beneton, Veronique; Boullay, Anne-Benedict; Boyer, Thierry; Brewster, Andrew G.; Donche, Frederic; Forest, Marie-Claire; Fouchet, Marie-Helene; Gellibert, Francoise J.; Grillot, Didier A.; Lambert, Millard H.; Laroze, Alain; Le Grumelec, Christelle; Linget, Jean Michel; Montana, Valerie G.; Nguyen, Van-Loc; Nicodeme, Edwige; Patel, Vipul; Penfornis, Annie; Pineau, Olivier; Pohin, Danig; Potvain, Florent; Poulain, Geraldine; Ruault, Cecile Bertho; Saunders, Michael; Toum, Jerome; Xu, H. Eric; Xu, Robert X.; Pianetti, Pascal M. Journal of Medicinal Chemistry, 2007 , vol. 50, # 4 p. 685 - 695
  • Route2

    References

    • WO2004/785 A2, ; Page 20 ; WO 2004/000785 A2
  • Route3

    References

    • Journal of Medicinal Chemistry, , vol. 50, # 4 p. 685 - 695

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   50.19
  • LogP   3.83552
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   2

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