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Ethyl 2-amino-4-phenylthiazole-5-carboxylate

  • CAS No. 64399-23-1

  • Cat. No. CS-0071496
  • Purity≥98%
  • MDL No.MFCD00022452

*For research and further manufacturing use only, not for direct human use.

Ethyl 2-amino-4-phenylthiazole-5-carboxylate|CS-0071496

Structure of 64399-23-1

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General Information

  • CAS No. 64399-23-1
  • Cat. No. CS-0071496
  • Purity ≥98%
  • MDL No. MFCD00022452
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₂H₁₂N₂O₂S
  • Molecular Weight 248.30
  • Synonym(s) 2-Amino-4-phenylthiazole-5-carboxylic Acid Ethyl Ester
  • SMILES O=C(OCC)C1=C(C2=CC=CC=C2)N=C(N)S1

Application

Ethyl 2-amino-4-phenylthiazole-5-carboxylate serves as a versatile building block in heterocyclic synthesis, enabling efficient access to thiazole-based scaffolds through established coupling and functionalization protocols. The molecule exhibits bench stability, tolerates diverse reaction conditions, and facilitates straightforward purification due to its crystalline nature. Its amino and ester functionalities support sequential transformations, making it particularly valuable for medicinal chemistry and process development workflows requiring modular scaffold construction.

Synthesis

  • Route1

    References

    • Ladouceur, Gaetan H.; Bullock, William H.; Magnuson, Steven R.; O'Connor, Stephen J.; Smith, Roger A.; Shen, Quanrong; Liu, Qingjie; Su, Ning; Velthuisen, Emil J.; Campbell, Ann-Marie; Ehrlich, Paul P. Patent: US2003/78258 A1, 2003 ;
  • Route2
    • In-stock
      Ethyl 2-chloro-3-oxo-3-phenylpropanoate|CS-0230692
      41381-97-9
    • null|null
      17356-08-0
    • ~87%
    • In-stock
      Ethyl 2-amino-4-phenylthiazole-5-carboxylate|CS-0071496
      64399-23-1

    References

    • Ladouceur, Gaetan H.; Schoen, William R.; Burke, Michael J. Patent: US2003/195352 A1, 2003 ; Location in patent: Page/Page column 35 ;
  • Route3
    • null|null
      34320-89-3
    • null|null
      17356-08-0
    • ~%
    • In-stock
      Ethyl 2-amino-4-phenylthiazole-5-carboxylate|CS-0071496
      64399-23-1

    References

    • Tetrahedron, , vol. 68, # 1 p. 173 - 178

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H319
Precautionary Statements : P264-P270-P280-P330-P501

Quality Control

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Computational Chemistry Data

  • TPSA   65.21
  • LogP   2.569
  • H_Acceptors   5
  • H_Donors   1
  • Rotatable_Bonds   3

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