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CS-W001157 4
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7-Bromo-1-methyl-1H-pyrrolo[3,2-c]pyridine

  • CAS No. 1440520-76-2

  • Cat. No. CS-0476366
  • Purity≥98%
  • MDL No.MFCD28501789

*For research and further manufacturing use only, not for direct human use.

7-Bromo-1-methyl-1H-pyrrolo[3,2-c]pyridine|CS-0476366

Structure of 1440520-76-2

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General Information

  • CAS No. 1440520-76-2
  • Cat. No. CS-0476366
  • Purity ≥98%
  • MDL No. MFCD28501789
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₇BrN₂
  • Molecular Weight 211.06
  • Synonym(s) None
  • SMILES CN1C=CC2=C1C(Br)=CN=C2

Description

7-Bromo-1-methyl-1H-pyrrolo[3,2-c]pyridine is a heterocyclic scaffold featuring a brominated pyrrolopyridine core with a methyl group at the nitrogen. This electron-deficient system enables efficient coupling in cross-coupling reactions and serves as a key building block for pharmaceutical intermediates and functional materials. The molecule exhibits enhanced stability and solubility under standard reaction conditions.

Application

7-Bromo-1-methyl-1H-pyrrolo[3,2-c]pyridine serves as a versatile building block in medicinal chemistry, enabling direct functionalization at the bromo position via Pd-catalyzed cross-coupling reactions. The methyl group enhances solubility and modulates electronic properties, while the pyrrolo[3,2-c]pyridine core provides a rigid, planar scaffold suitable for kinase inhibitors and other bioactive heterocycles. Bench-stable and compatible with standard synthetic workflows, it facilitates efficient access to complex nitrogen-containing architectures.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   17.82
  • LogP   2.3358
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   0

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