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CS-W001157 4
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3-(4-chlorobutyl)-1H-indole-5-carbonitrile

  • CAS No. 143612-79-7

  • Cat. No. CS-M1251
  • Purity≥95%
  • MDL No.MFCD09833261
  • HazMat Fee +

    HazMat Fee

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

3-(4-chlorobutyl)-1H-indole-5-carbonitrile|CS-M1251

Structure of 143612-79-7

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Description

3-(4-chlorobutyl)-1H-indole-5-carbonitrile features a reactive chloroalkyl tether appended to the indole core, enabling site-specific conjugation in bioconjugation and medicinal chemistry. The para-cyano group enhances electronic withdrawal, while the aliphatic chain offers flexible spacing. This compound serves as a modular building block for targeted probe development and functional material synthesis under standard conditions.

Application

3-(4-Chlorobutyl)-1H-indole-5-carbonitrile serves as a versatile building block for indole-based heterocycles, enabling efficient functionalization via nucleophilic substitution. The pendant chloroalkyl chain facilitates facile conjugation with amines, thiols, and other nucleophiles, while the nitrile group provides compatibility with standard transformations including hydrolysis or reductive amination. Its bench-stable nature and straightforward purification make it well-suited for medicinal chemistry campaigns and API intermediate synthesis.

General Information

  • CAS No. 143612-79-7
  • Cat. No. CS-M1251
  • Purity ≥95%
  • MDL No. MFCD09833261
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₃H₁₃ClN₂
  • Molecular Weight 232.71
  • Synonym(s) Vilazodone Intermediate 8; 3-(4-Chlorobutyl)-1H-indole-5-carbonitrile
  • SMILES ClCCCCC1=CNC2=CC=C(C#N)C=C21

Computational Chemistry Data

  • TPSA   39.58
  • LogP   3.60108
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   4

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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