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CS-W001157 4
Total: USD 88.00

4,5-Dichloro-1H-imidazole

  • CAS No. 15965-30-7

  • Cat. No. CS-0074351
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

4,5-Dichloro-1H-imidazole|CS-0074351

Structure of 15965-30-7

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General Information

  • CAS No. 15965-30-7
  • Cat. No. CS-0074351
  • Purity ≥97%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₃H₂Cl₂N₂
  • Molecular Weight 136.97
  • Synonym(s) Dichloroimidazole
  • SMILES ClC1=C(Cl)N=CN1

Description

4,5-Dichloroimidazole has been used in the synthesis of:phosphinite complexes1-hexyl-3-methyl-4,5-dichloroimidazolium iodide, precursor required for the preparation of silver-carbene complex-loaded into L-tyrosine polyphosphate nanoparticles

Application

4,5-Dichloro-1H-imidazole serves as a versatile building block in medicinal chemistry, enabling the synthesis of substituted imidazoles via palladium-catalyzed cross-coupling and nucleophilic displacement reactions. Its dichloro substitution pattern provides orthogonal reactivity for sequential functionalization, while its bench-stable crystalline form facilitates handling and purification in multi-step syntheses.

Synthesis

  • Route1
    • Imidazole Ondansetron Impurity|CS-0229601
      288-32-4
    • ~80%
    • In-stock
      4,5-Dichloro-1H-imidazole|CS-0074351
      15965-30-7

    References

    • Sandtorv, Alexander H.; Bjorsvik, Hans-Rene Advanced Synthesis and Catalysis, 2013 , vol. 355, # 2-3 p. 499 - 507
  • Route2
    • Imidazole Ondansetron Impurity|CS-0229601
      288-32-4
    • ~19%
    • In-stock
      5-Chloro-1H-imidazole|CS-W018584
      15965-31-8
    • In-stock
      4,5-Dichloro-1H-imidazole|CS-0074351
      15965-30-7

    References

    • Journal of Organic Chemistry, , vol. 63, # 25 p. 9448 - 9454
  • Route3
    • 4,5-Dichloro-1h-imidazole-2-carboxylic acid|CS-0186909
      64736-53-4
    • ~61%
    • In-stock
      4,5-Dichloro-1H-imidazole|CS-0074351
      15965-30-7

    References

    • Sundermeyer, Joerg; Roesky, Herbert W. Angewandte Chemie, 1988 , vol. 100, # 10 p. 1417 - 1418

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   28.68
  • LogP   1.7165
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   0

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