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Methyl 7-bromo-1H-indazole-5-carboxylate

  • CAS No. 1427460-96-5

  • Cat. No. CS-0041393
  • Purity≥97%
  • MDL No.MFCD22421936

*For research and further manufacturing use only, not for direct human use.

Methyl 7-bromo-1H-indazole-5-carboxylate|CS-0041393

Structure of 1427460-96-5

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General Information

  • CAS No. 1427460-96-5
  • Cat. No. CS-0041393
  • Purity ≥97%
  • MDL No. MFCD22421936
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₇BrN₂O₂
  • Molecular Weight 255.07
  • Synonym(s) 7-Bromo-1H-indazole-5-carboxylic acid methyl ester
  • SMILES O=C(C1=CC2=C(NN=C2)C(Br)=C1)OC

Description

Methyl 7-bromo-1H-indazole-5-carboxylate features a brominated indazole core with a methyl ester at the 5-position, enabling direct functionalization in cross-coupling and derivatization workflows. The electron-deficient heterocycle pairs effectively with palladium catalysts, while the ester group offers synthetic handle versatility under standard conditions.

Application

Methyl 7-bromo-1H-indazole-5-carboxylate serves as a versatile building block for the synthesis of indazole-based pharmaceutical intermediates. The bromo group enables palladium-catalyzed cross-coupling reactions, while the ester functionality supports selective transformations including hydrolysis and reduction. Its bench-stable nature and compatibility with diverse reaction conditions make it well-suited for iterative synthetic sequences in medicinal chemistry and API development.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   54.98
  • LogP   2.112
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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