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CS-W001157 4
Total: USD 88.00

7-Bromobenzo[b]thiophene

  • CAS No. 1423-61-6

  • Cat. No. CS-0102956
  • Purity≥98%
  • MDL No.MFCD06657729

*For research and further manufacturing use only, not for direct human use.

7-Bromobenzo[b]thiophene|CS-0102956

Structure of 1423-61-6

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General Information

  • CAS No. 1423-61-6
  • Cat. No. CS-0102956
  • Purity ≥98%
  • MDL No. MFCD06657729
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₅BrS
  • Molecular Weight 213.09
  • Synonym(s) Brexpiprazole Impurity 7-bromobenzo[b]thiophene
  • SMILES BrC1=C2C(C=CS2)=CC=C1

Description

7-Bromobenzo[b]thiophene serves as a key heterocyclic building block in the synthesis of functional organic materials. This brominated scaffold enables efficient cross-coupling reactions, offering high reactivity and stability under standard conditions. The fused benzothiophene core provides enhanced electron density and planarity, facilitating applications in pharmaceutical development and advanced materials science.

Application

7-Bromobenzo[b]thiophene serves as a versatile building block in synthetic organic chemistry, enabling palladium-catalyzed cross-coupling reactions such as Suzuki, Stille, and Negishi couplings. Its bromine substituent provides high reactivity under standard conditions, while the fused thiophene core offers excellent bench stability and compatibility with diverse functional groups. This compound facilitates efficient construction of complex heterocyclic scaffolds relevant to medicinal chemistry and materials science.

Synthesis

  • Route1
    • (2-Bromophenyl)(2,2-diethoxyethyl)sulfane|CS-0151530
      137105-52-3
    • ~94%
    • In-stock
      7-Bromobenzo[b]thiophene|CS-0102956
      1423-61-6

    References

    • Eli Lilly and Company Patent: US6353008 B1, 2002 ; Location in patent: Page column 26 ; US 6353008 B1
  • Route2
    • (2-Bromophenyl)(2,2-dimethoxyethyl)sulfane|CS-0302160
      799766-06-6
    • ~90%
    • In-stock
      7-Bromobenzo[b]thiophene|CS-0102956
      1423-61-6

    References

    • WYETH Patent: WO2004/103941 A2, 2004 ; Location in patent: Page 23 ; WO 2004/103941 A2
  • Route3
    • null|null
      864684-51-5
    • ~%
    • In-stock
      7-Bromobenzo[b]thiophene|CS-0102956
      1423-61-6

    References

    • EP1724277 A1, ; Page/Page column 29 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   0
  • LogP   3.6638
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   0

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