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CS-W001157 4
Total: USD 88.00

7-Bromobenzofuran

  • CAS No. 133720-60-2

  • Cat. No. CS-W019960
  • Purity≥98%
  • MDL No.MFCD09056756

*For research and further manufacturing use only, not for direct human use.

7-Bromobenzofuran|CS-W019960

Structure of 133720-60-2

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General Information

  • CAS No. 133720-60-2
  • Cat. No. CS-W019960
  • Purity ≥98%
  • MDL No. MFCD09056756
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₅BrO
  • Molecular Weight 197.03
  • Synonym(s) 7-Bromobenzo[b]furan; 7-Bromo-1-benzofuran
  • SMILES BrC1=C(OC=C2)C2=CC=C1

Description

7-Bromobenzofuran is a brominated heterocyclic compound featuring a benzofuran core with a bromine substituent at the 7-position. This electron-deficient scaffold serves as a key building block in synthetic organic chemistry, particularly in cross-coupling reactions and the development of functional materials. The bromine atom enables direct functionalization under palladium-catalyzed conditions, facilitating efficient access to complex molecular architectures. Its stability under standard handling protocols supports reliable use in process development workflows.

Application

7-Bromobenzofuran serves as a versatile building block in synthetic organic chemistry, enabling palladium-catalyzed cross-coupling reactions such as Suzuki-Miyaura and Stille couplings. Its bromine substituent provides high reactivity under standard conditions, while the benzofuran core offers excellent stability and compatibility with diverse functional groups. This compound facilitates efficient access to biaryl architectures and complex heterocyclic scaffolds relevant to medicinal chemistry and materials science.

Synthesis

  • Route1
    • 1-Bromo-2-(2,2-diethoxyethoxy)benzene|CS-0450386
      253429-15-1
    • ~71%
    • In-stock
      7-Bromobenzofuran|CS-W019960
      133720-60-2

    References

    • Eli Lilly and Company Patent: US6353008 B1, 2002 ; Location in patent: Page column 38 ; US 6353008 B1
  • Route2
    • 1-Bromo-3-(2,2-diethoxyethoxy)benzene|CS-1143544
      204452-94-8
    • ~%
    • In-stock
      6-Bromobenzofuran|CS-W005044
      128851-73-0
    • In-stock
      7-Bromobenzofuran|CS-W019960
      133720-60-2

    References

    • US2010/280013 A1, ; Page/Page column 42 ;
  • Route3
    • null|null
      95-56-7
    • ~%
    • In-stock
      4-Bromobenzofuran|CS-0054114
      128868-60-0
    • In-stock
      7-Bromobenzofuran|CS-W019960
      133720-60-2

    References

    • EP1204654 B1, ; EP 1204654 B1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   13.14
  • LogP   3.1953
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   0

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