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CS-W001157 4
Total: USD 88.00

(S)-4-CF3-Pyox-iPr

  • CAS No. 1416820-34-2

  • Cat. No. CS-0104451
  • Purity≥97%
  • MDL No.MFCD32670812

*For research and further manufacturing use only, not for direct human use.

(S)-4-CF3-Pyox-iPr|CS-0104451

Structure of 1416820-34-2

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General Information

  • CAS No. 1416820-34-2
  • Cat. No. CS-0104451
  • Purity ≥97%
  • MDL No. MFCD32670812
  • Storage -20°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₂H₁₃F₃N₂O
  • Molecular Weight None
  • Synonym(s) None
  • SMILES CC(C)[C@@H](CO1)N=C1C2=NC=CC(C(F)(F)F)=C2

Description

(S)-4-CF3-Pyox-iPr is a bench-stable, moisture-tolerant chiral pyridine derivative featuring a trifluoromethyl group at the 4-position and an isopropyl substituent on the oxime nitrogen. This configuration enhances stereochemical control in asymmetric synthesis, enabling efficient coupling in transition-metal-catalyzed transformations and providing robust performance under standard reaction conditions.

Application

(S)-4-CF₃-Pyox-iPr serves as a robust chiral auxiliary in asymmetric synthesis, enabling stereoselective transformations through its stable pyrrolidine scaffold. The trifluoromethyl group enhances electronic polarization and metabolic stability, while the isopropyl substituent improves solubility and facilitates purification. This reagent reliably participates in standard amine alkylation, acylation, and conjugate addition reactions, offering high enantioselectivity and bench stability under ambient conditions.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   34.48
  • LogP   2.9018
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   2

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