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CS-W001157 4
Total: USD 88.00

(4,5-Difluoro-2-methylphenyl)boronic acid

  • CAS No. 1416244-48-8

  • Cat. No. CS-B1253
  • Purity≥98%
  • MDL No.MFCD12911676

*For research and further manufacturing use only, not for direct human use.

(4,5-Difluoro-2-methylphenyl)boronic acid|CS-B1253

Structure of 1416244-48-8

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General Information

  • CAS No. 1416244-48-8
  • Cat. No. CS-B1253
  • Purity ≥98%
  • MDL No. MFCD12911676
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₇BF₂O₂
  • Molecular Weight 171.94
  • Synonym(s) 4,5-difluoro-2-methylphenylboronic acid
  • SMILES CC1=CC(F)=C(F)C=C1B(O)O

Description

This difluorinated boronic acid integrates a methyl-substituted aryl moiety with enhanced stability and improved solubility in polar solvents. The ortho-fluoro groups facilitate efficient Suzuki-Miyaura coupling, enabling rapid construction of complex biaryl architectures under standard conditions.

Application

(4,5-Difluoro-2-methylphenyl)boronic acid serves as a versatile building block in Suzuki-Miyaura cross-coupling reactions, enabling efficient C–C bond formation under mild conditions. Its ortho-fluoro substituents enhance stability and modulate reactivity, while the methyl group provides steric and electronic tuning for downstream functionalization. The boronic acid is bench-stable, readily purified by recrystallization, and compatible with diverse reaction matrices, making it well-suited for medicinal chemistry and process development workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H312-H332
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P501

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Computational Chemistry Data

  • TPSA   40.46
  • LogP   -0.04698
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   1

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