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CS-W001157 4
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(4R,4'R)-4,4'-DiBenzyl-4,4',5,5'-tetrahydro-2,2'-bioxazole

  • CAS No. 141362-76-7

  • Cat. No. CS-0097369
  • Molecule weight320.39
  • Purity≥95%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

(4R,4'R)-4,4'-DiBenzyl-4,4',5,5'-tetrahydro-2,2'-bioxazole|CS-0097369

Structure of 141362-76-7

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General Information

  • CAS No. 141362-76-7
  • Cat. No. CS-0097369
  • Purity ≥95%
  • MDL No. None
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₂₀H₂₀N₂O₂
  • Molecular Weight 320.39
  • Synonym(s) 2,2'-Bioxazole, 4,4',5,5'-tetrahydro-4,4'-bis(phenylmethyl)-, [R-(R*,R*)]- (9CI)
  • SMILES C1(C2=N[C@H](CC3=CC=CC=C3)CO2)=N[C@H](CC4=CC=CC=C4)CO1

Description

(R,R)-Bn-Bisbox is a chiral bis(oxazoline) ligand featuring benzyl-protected pyridine units, designed for asymmetric catalysis. This bench-stable, moisture-tolerant scaffold integrates two rigid oxazoline rings flanking a central chiral backbone, enabling precise stereocontrol in transition-metal-catalyzed transformations.

Application

(R,R)-Bn-Bisbox serves as a robust chiral ligand in asymmetric catalysis, enabling high enantioselective transformations in transition-metal-catalyzed reactions. Its bis(oxazoline) architecture with benzylic substitution provides excellent stereocontrol and bench stability, facilitating efficient synthesis of chiral building blocks. The ligand exhibits broad functional group tolerance and is compatible with standard purification methods, making it a practical choice for scalable asymmetric synthesis.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   43.18
  • LogP   3.0664
  • H_Acceptors   4
  • H_Donors   0
  • Rotatable_Bonds   5

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