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tert-Butyl 7-oxo-5-oxa-2-azaspiro[3.4]octane-2-carboxylate

  • CAS No. 1408075-90-0

  • Cat. No. CS-0037179
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

tert-Butyl 7-oxo-5-oxa-2-azaspiro[3.4]octane-2-carboxylate|CS-0037179

Structure of 1408075-90-0

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General Information

  • CAS No. 1408075-90-0
  • Cat. No. CS-0037179
  • Purity ≥97%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₁₇NO₄
  • Molecular Weight 227.26
  • Synonym(s) None
  • SMILES CC(C)(C)OC(=O)N1CC2(CC(=O)CO2)C1

Description

tert-Butyl 7-oxo-5-oxa-2-azaspiro[3.4]octane-2-carboxylate features a spirocyclic scaffold integrating a lactam and ether linkage, offering a rigid, electron-deficient core for targeted synthesis. This bench-stable, moisture-tolerant building block enables efficient access to complex heterocycles in medicinal chemistry and natural product analogs.

Application

tert-Butyl 7-oxo-5-oxa-2-azaspiro[3.4]octane-2-carboxylate serves as a versatile spirocyclic building block for the synthesis of nitrogen-containing heterocycles. Its constrained bicyclic framework features a ketone, an ester, and a lactam-like nitrogen functionality, enabling selective transformations under mild conditions. The tert-butyl ester group provides bench stability and facilitates straightforward deprotection. This scaffold enables efficient access to complex polycyclic architectures relevant in medicinal chemistry.

Safety Information

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GHS Pictogram :
GHS No : GHS06
Signal Word : Danger
UN#: 2811
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H301
Precautionary Statements : P264-P270-P330-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   55.84
  • LogP   0.9653
  • H_Acceptors   4
  • H_Donors   0
  • Rotatable_Bonds   0

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