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CS-W001157 4
Total: USD 88.00

2-(Trifluoromethyl)pyridin-4-ol

  • CAS No. 170886-13-2

  • Cat. No. CS-W019423
  • Molecule weight163.10
  • Purity≥98%
  • MDL No.MFCD01571202

*For research and further manufacturing use only, not for direct human use.

2-(Trifluoromethyl)pyridin-4-ol|CS-W019423

Structure of 170886-13-2

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General Information

  • CAS No. 170886-13-2
  • Cat. No. CS-W019423
  • Purity ≥98%
  • MDL No. MFCD01571202
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₄F₃NO
  • Molecular Weight 163.10
  • Synonym(s) None
  • SMILES OC1=CC(C(F)(F)F)=NC=C1

Description

2-(Trifluoromethyl)pyridin-4-ol features a trifluoromethyl group at the ortho position relative to a phenolic hydroxyl, imparting enhanced electron-withdrawing character and improved metabolic stability. The pyridinic nitrogen provides a polar, basic site for coordination or derivatization. This combination enables direct incorporation into bioactive scaffolds and functional materials requiring both solubility and resistance to oxidative degradation under standard conditions.

Application

2-(Trifluoromethyl)pyridin-4-ol serves as a versatile building block in medicinal chemistry, enabling efficient access to functionalized heterocycles through direct coupling and electrophilic substitution. Its trifluoromethyl group enhances metabolic stability and modulates electronic properties, while the phenolic hydroxyl offers a reliable handle for derivatization via etherification or esterification. The compound exhibits good bench stability and compatibility with common reaction conditions, facilitating integration into multi-step syntheses of bioactive molecules.

Synthesis

  • Route1
    • null|null
      1297137-35-9
    • null|null
      1297137-78-0
    • ~78%
    • In-stock
      2-(Trifluoromethyl)pyridin-4-ol|CS-W019423
      170886-13-2

    References

    • WO2011/50284 A1, ; Page/Page column 127 ;
  • Route2
    • null|null
      1297136-80-1
    • ~%
    • In-stock
      2-(Trifluoromethyl)pyridin-4-ol|CS-W019423
      170886-13-2

    References

    • WO2011/50284 A1, ;
  • Route3
    • 5-Methoxy-7-(trifluoromethyl)pyrazolo[1,5-a]pyridine-2-carboxylic acid|CS-0713350
      1297136-82-3
    • ~%
    • In-stock
      2-(Trifluoromethyl)pyridin-4-ol|CS-W019423
      170886-13-2

    References

    • WO2011/50284 A1, ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   33.12
  • LogP   1.806
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

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