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tert-Butyl 7-oxo-2-azaspiro[3.5]nonane-2-carboxylate

  • CAS No. 1363381-22-9

  • Cat. No. CS-0048134
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

tert-Butyl 7-oxo-2-azaspiro[3.5]nonane-2-carboxylate|CS-0048134

Structure of 1363381-22-9

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General Information

  • CAS No. 1363381-22-9
  • Cat. No. CS-0048134
  • Purity ≥97%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₃H₂₁NO₃
  • Molecular Weight 239.31
  • Synonym(s) tert-Butyl 7-Oxo-2-aza-spiro3.5none-2-carboxylate
  • SMILES CC(C)(C)OC(=O)N1CC2(C1)CCC(=O)CC2

Description

tert-Butyl 7-oxo-2-azaspiro[3.5]nonane-2-carboxylate is a sterically shielded spirocyclic lactam precursor featuring a bench-stable ketone at the C7 position and a protected carboxylic acid ester at C2. This scaffold integrates seamlessly into complex nitrogen-containing heterocycles, enabling efficient access to bioactive alkaloid frameworks through mild deprotection and functionalization.

Application

tert-Butyl 7-oxo-2-azaspiro[3.5]nonane-2-carboxylate serves as a versatile spirocyclic building block for the synthesis of nitrogen-containing heterocycles, particularly in medicinal chemistry and natural product derivatization. The molecule combines a stable tert-butyl ester with a ketone at C7 and a secondary amine at C2, enabling selective functionalization via reductive amination, enolate chemistry, or nucleophilic addition. Its rigid spiro scaffold enhances conformational control, while the bench-stable nature and straightforward purification support scalable applications in multi-step synthesis.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   46.61
  • LogP   2.3666
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   0

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