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CS-W001157 4
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tert-Butyl N-[(1-aminocyclobutyl)methyl]carbamate

  • CAS No. 1403767-13-4

  • Cat. No. CS-0040899
  • Molecule weight200.28
  • Purity≥97%
  • MDL No.MFCD23106332

*For research and further manufacturing use only, not for direct human use.

tert-Butyl N-[(1-aminocyclobutyl)methyl]carbamate|CS-0040899

Structure of 1403767-13-4

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General Information

  • CAS No. 1403767-13-4
  • Cat. No. CS-0040899
  • Purity ≥97%
  • MDL No. MFCD23106332
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₂₀N₂O₂
  • Molecular Weight 200.28
  • Synonym(s) TERT-BUTYLN-[(1-AMINOCYCLOBUTYL)METHYL]CARBAMATE
  • SMILES O=C(OC(C)(C)C)NCC1(N)CCC1

Description

tert-Butyl N-[(1-aminocyclobutyl)methyl]carbamate is a bench-stable, moisture-tolerant protecting group for primary amines, featuring a cyclobutylmethyl scaffold that enables selective derivatization in complex molecule synthesis. This carbamate delivers enhanced solubility in polar organic solvents and facilitates straightforward deprotection under mild acidic conditions, streamlining access to functionalized cyclobutylamine intermediates.

Application

tert-Butyl N-[(1-aminocyclobutyl)methyl]carbamate serves as a versatile building block for cyclobutyl-containing scaffolds in medicinal chemistry. The carbamate group provides stability and facilitates orthogonal deprotection, while the primary amine enables direct coupling or derivatization. Its bench-stable nature and compatibility with standard peptide coupling protocols make it ideal for modular synthesis of bioactive compounds.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   64.35
  • LogP   1.3925
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   2

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