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CS-W001157 4
Total: USD 88.00

4-((4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)sulfonyl)morpholine

  • CAS No. 1401222-64-7

  • Cat. No. CS-0175643
  • Molecule weight353.24
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

4-((4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)sulfonyl)morpholine|CS-0175643

Structure of 1401222-64-7

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General Information

  • CAS No. 1401222-64-7
  • Cat. No. CS-0175643
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₆H₂₄BNO₅S
  • Molecular Weight 353.24
  • Synonym(s) 4-[4-(tetramethyl-1,3,2-dioxaborolan-2-yl)benzenesulfonyl]morpholine
  • SMILES CC1(C(C)(OB(O1)C2=CC=C(S(=O)(N3CCOCC3)=O)C=C2)C)C

Description

This morpholine derivative features a boronate ester group integrated with a sulfonamide linker, enabling efficient Suzuki-Miyaura coupling under standard conditions. The tetramethyl-1,3,2-dioxaborolane moiety imparts excellent stability and reactivity, while the electron-rich morpholine ring enhances solubility in polar solvents. This combination facilitates reliable incorporation into complex molecular architectures during synthetic workflows.

Application

4-((4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)sulfonyl)morpholine serves as a versatile boronate building block for Suzuki-Miyaura cross-coupling reactions. The morpholine sulfone moiety imparts excellent bench stability and solubility, while the pinacol boronate group enables efficient coupling with aryl halides under mild conditions. Its functional group tolerance and ease of purification make it a practical reagent for constructing complex aromatic scaffolds in medicinal chemistry and materials science applications.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   65.07
  • LogP   1.0067
  • H_Acceptors   5
  • H_Donors   0
  • Rotatable_Bonds   3

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