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CS-W001157 4
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2-Oxa-7-azaspiro[3.5]nonane

  • CAS No. 241820-91-7

  • Cat. No. CS-0003855
  • Purity≥97%
  • MDL No.MFCD11035888

*For research and further manufacturing use only, not for direct human use.

2-Oxa-7-azaspiro[3.5]nonane|CS-0003855

Structure of 241820-91-7

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General Information

  • CAS No. 241820-91-7
  • Cat. No. CS-0003855
  • Purity ≥97%
  • MDL No. MFCD11035888
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₁₃NO
  • Molecular Weight 127.18
  • Synonym(s) 2-Oxa-7-aza-spiro3.5none
  • SMILES C12(CCNCC2)COC1

Description

2-Oxa-7-azaspiro[3.5]nonane features a rigid spirocyclic architecture integrating an oxygen atom and a nitrogen heteroatom within a fused seven-membered ring system. This configuration imparts enhanced conformational stability and polar functionality, enabling its use as a scaffold in medicinal chemistry for targeted molecular recognition and improved solubility in drug discovery applications.

Application

2-Oxa-7-azaspiro[3.5]nonane serves as a rigid, bicyclic scaffold with orthogonal functional group handles, enabling efficient access to spirocyclic libraries in medicinal chemistry. Its stability under standard reaction conditions and compatibility with diverse coupling protocols facilitate rapid diversification. The embedded ether and amine functionalities support derivatization via alkylation, acylation, or reductive amination, making it a practical building block for targeted compound synthesis.

Synthesis

  • Route1
    • null|null
      1349875-67-7
    • ~79%
    • In-stock
      2-Oxa-7-azaspiro[3.5]nonane|CS-0003855
      241820-91-7

    References

    • AMGEN INC.; ALLEN, Jennifer R.; CHEN, Jian J.; FROHN, Michael J.; HU, Essa; LIU, Qingyian; PICKRELL, Alexander J.; RUMFELT, Shannon; RZASA, Robert M.; ZHONG, Wenge Patent: WO2011/143365 A1, 2011 ; Location in patent: Page/Page column 191 ; WO 2011/143365 A1
  • Route2

    References

    • Castro Pineiro, Jose Luis; Dinnell, Kevin; Elliott, Jason Matthew; Hollingworth, Gregory John; Shaw, Duncan Edward; Swain, Christopher John Patent: US2003/236250 A1, 2003 ; Location in patent: Page 28 ;
  • Route3
    • Benzyl 2-oxa-7-azaspiro[3.5]Nonane-7-carboxylate|CS-0476016
      1313369-55-9
    • ~%
    • In-stock
      2-Oxa-7-azaspiro[3.5]nonane|CS-0003855
      241820-91-7

    References

    • Tetrahedron Letters, , vol. 52, # 26 p. 3266 - 3270

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 2735
Class : 8
Packing Group : Ⅲ
Hazard Statements : H314
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   21.26
  • LogP   0.3864
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

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