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CS-W001157 4
Total: USD 88.00

1,2,3,4-Tetrahydro-1,5-naphthyridine

  • CAS No. 13993-61-8

  • Cat. No. CS-W006541
  • Purity≥95%
  • MDL No.MFCD08444439

*For research and further manufacturing use only, not for direct human use.

1,2,3,4-Tetrahydro-1,5-naphthyridine|CS-W006541

Structure of 13993-61-8

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General Information

  • CAS No. 13993-61-8
  • Cat. No. CS-W006541
  • Purity ≥95%
  • MDL No. MFCD08444439
  • Storage RT, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₁₀N₂
  • Molecular Weight None
  • Synonym(s) 1,2,3,4-Tetrahydro-1,5phthyridine
  • SMILES C12=NC=CC=C1NCCC2

Description

1,2,3,4-Tetrahydro-1,5-naphthyridine delivers a rigid, electron-rich heterocyclic scaffold ideal for medicinal chemistry. This bench-stable compound integrates readily into target molecules, offering enhanced solubility and metabolic stability in drug discovery applications.

Application

1,2,3,4-Tetrahydro-1,5-naphthyridine serves as a versatile heterocyclic building block in medicinal chemistry, enabling efficient access to nitrogen-containing scaffolds via standard functionalization protocols. Its stable, bench-ready structure exhibits excellent tolerance to common reaction conditions and facilitates downstream derivatization, including coupling reactions and ring expansion processes.

Synthesis

  • Route1

    References

    • Xie, Xu; Freed, Dana A.; Kozlowski, Marisa C. Tetrahedron Letters, 2001 , vol. 42, # 37 p. 6451 - 6454
  • Route2
    • null|null
      198549-21-2
    • ~87%
    • In-stock
      1,2,3,4-Tetrahydro-1,5-naphthyridine|CS-W006541
      13993-61-8

    References

    • Lahue, Brian R.; Lo, Sie-Mun; Wan, Zhao-Kui; Woo, Grace H. C.; Snyder, John K. Journal of Organic Chemistry, 2004 , vol. 69, # 21 p. 7171 - 7182
  • Route3
    • null|null
      198549-21-2
    • ~35%
    • In-stock
      1,5-Naphthyridine|CS-B0780
      254-79-5
    • In-stock
      1,2,3,4-Tetrahydro-1,5-naphthyridine|CS-W006541
      13993-61-8

    References

    • Tetrahedron Letters, , vol. 38, # 43 p. 7499 - 7502

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319
Precautionary Statements : P264-P270-P280-P301+P310-P302+P352-P305+P351+P338-P330-P332+P313-P337+P313-P362+P364-P501

Quality Control

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Computational Chemistry Data

  • TPSA   24.92
  • LogP   1.4397
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

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