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4-Amino-1-methyl-3-N-propyl-1H-pyrazole-5-carboxamide Sildenafil Impurity

  • CAS No. 139756-02-8

  • Cat. No. CS-0229523
  • Purity≥98%
  • MDL No.MFCD02927682

*For research and further manufacturing use only, not for direct human use.

4-Amino-1-methyl-3-N-propyl-1H-pyrazole-5-carboxamide Sildenafil Impurity|CS-0229523

Structure of 139756-02-8

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General Information

  • CAS No. 139756-02-8
  • Cat. No. CS-0229523
  • Purity ≥98%
  • MDL No. MFCD02927682
  • Storage Sealed in dry,2-8℃
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₁₄N₄O
  • Molecular Weight 182.23
  • Synonym(s) 4-Amino-1-Methyl-3-Propyl-5-Pyrazolecarboxamide
  • SMILES O=C(N)C1=C(N)C(=NN1C)CCC

Synthesis

  • Route1
    • 1-Methyl-3-propyl-1H-pyrazole-5-carboxylic acid|CS-0006634
      139755-99-0
    • ~%
    • 4-Amino-1-methyl-3-N-propyl-1H-pyrazole-5-carboxamide Sildenafil Impurity|CS-0229523
      139756-02-8

    References

    • Bioorganic and Medicinal Chemistry Letters, , vol. 6, # 15 p. 1819 - 1824
  • Route2

    References

    • AUSPEX PHARMACEUTICALS, INC. Patent: US2008/194529 A1, 2008 ; Location in patent: Page/Page column 57 ; US 20080194529 A1
  • Route3
    • 1-methyl-4-nitro-3-propyl-1H-pyrazole-5-carboxylic acid  Sildenafil Impurity|CS-0166496
      139756-00-6
    • ~%
    • 4-Amino-1-methyl-3-N-propyl-1H-pyrazole-5-carboxamide Sildenafil Impurity|CS-0229523
      139756-02-8

    References

    • Bioorganic and Medicinal Chemistry Letters, , vol. 15, # 17 p. 3900 - 3907

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352

Quality Control

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Computational Chemistry Data

  • TPSA   86.93
  • LogP   0.0537
  • H_Acceptors   4
  • H_Donors   2
  • Rotatable_Bonds   3

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