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CS-W001157 4
Total: USD 88.00

4-Amino-2-chloropyrimidine-5-carbaldehyde

  • CAS No. 1393547-54-0

  • Cat. No. CS-0157350
  • Purity≥97%
  • MDL No.MFCD22543997

*For research and further manufacturing use only, not for direct human use.

4-Amino-2-chloropyrimidine-5-carbaldehyde|CS-0157350

Structure of 1393547-54-0

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General Information

  • CAS No. 1393547-54-0
  • Cat. No. CS-0157350
  • Purity ≥97%
  • MDL No. MFCD22543997
  • Storage 4°C, protect from light, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₄ClN₃O
  • Molecular Weight 157.56
  • Synonym(s) 4-Amino-2-chloropyrimidine-5
  • SMILES O=CC1=CN=C(Cl)N=C1N

Description

4-Amino-2-chloropyrimidine-5-carbaldehyde features a reactive aldehyde group flanked by electron-rich amino and halogen-substituted pyrimidine moieties. This combination enables direct conjugation in synthetic routes targeting pharmaceutical intermediates, particularly in kinase inhibitor scaffolds. The molecule exhibits stability under standard bench conditions and facilitates efficient coupling without requiring protective group manipulation.

Application

4-Amino-2-chloropyrimidine-5-carbaldehyde serves as a versatile building block in medicinal chemistry, enabling efficient access to pyrimidine-based heterocycles. Its amino and chloro groups offer orthogonal reactivity for downstream functionalization, while the aldehyde moiety facilitates imine formation, reductive amination, or condensation reactions. Bench-stable and compatible with standard purification methods, it functions effectively in multi-step syntheses targeting kinase inhibitors and antiviral agents.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   68.87
  • LogP   0.5247
  • H_Acceptors   4
  • H_Donors   1
  • Rotatable_Bonds   1

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