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CS-W001157 4
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Methyl 5-aminopyrazine-2-carboxylate

  • CAS No. 13924-94-2

  • Cat. No. CS-W003640
  • Purity≥97%
  • MDL No.MFCD09753440

*For research and further manufacturing use only, not for direct human use.

Methyl 5-aminopyrazine-2-carboxylate|CS-W003640

Structure of 13924-94-2

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General Information

  • CAS No. 13924-94-2
  • Cat. No. CS-W003640
  • Purity ≥97%
  • MDL No. MFCD09753440
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₇N₃O₂
  • Molecular Weight 153.14
  • Synonym(s) Methyl 2-amino-5-pyrazinecarboxylate
  • SMILES COC(=O)c1cnc(cn1)N

Description

Methyl 5-aminopyrazine-2-carboxylate features a pyrazine core functionalized with an amino group at the 5-position and a methyl ester at the 2-position. This electron-rich heterocycle integrates readily into synthetic routes for pharmaceutical intermediates, offering enhanced solubility and stability under standard conditions.

Application

Methyl 5-aminopyrazine-2-carboxylate serves as a versatile heterocyclic building block for medicinal chemistry and agrochemical synthesis. The pyrazine core provides a rigid, electron-deficient platform amenable to palladium-catalyzed cross-coupling reactions. The amino and ester functionalities enable sequential derivatization—enabling access to diverse analogs via amidation, alkylation, or cyclization—while exhibiting good bench stability and straightforward purification by standard chromatography.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   78.1
  • LogP   -0.1546
  • H_Acceptors   5
  • H_Donors   1
  • Rotatable_Bonds   1

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