(2R)-Piperazine-1,2,4-tricarboxylic acid 4-benzyl ester 1-tert-butyl ester

Name: (2R)-Piperazine-1,2,4-tricarboxylic acid 4-benzyl ester 1-tert-butyl ester
Brand: ChemScene
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CAS No. 138775-02-7
Cat. No. CS-D1330
Purity≥96%
MDL No.MFCD02179112

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(2R)-Piperazine-1,2,4-tricarboxylic acid 4-benzyl ester 1-tert-butyl ester|CS-D1330

Structure of 138775-02-7

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General Information

CAS No. 138775-02-7
Cat. No. CS-D1330
Purity ≥96%
MDL No. MFCD02179112
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₈H₂₄N₂O₆
Molecular Weight 364.39
Synonym(s) (R)-4-((Benzyloxy)carbonyl)-1-(tert-butoxycarbonyl)piperazine-2-carboxylic acid
SMILES O=C(N1[C@@H](C(O)=O)CN(C(OCC2=CC=CC=C2)=O)CC1)OC(C)(C)C

Description

This piperazine derivative features a sterically shielded tert-butyl ester and a benzyl-protected carboxylic acid, enabling stable storage and selective deprotection. The (2R)-configured core provides defined stereochemistry for use in asymmetric synthesis and medicinal chemistry applications.

Application

(2R)-Piperazine-1,2,4-tricarboxylic acid 4-benzyl ester 1-tert-butyl ester serves as a versatile chiral building block for the synthesis of piperazine-based scaffolds. The tert-butyl and benzyl esters provide orthogonal protection, enabling selective deprotection during multi-step sequences. Its bench-stable nature and compatibility with standard coupling reactions facilitate efficient access to complex heterocyclic systems in medicinal chemistry and process development.

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

TPSA 96.38
LogP 2.3291
H_Acceptors 5
H_Donors 1
Rotatable_Bonds 3

Other Classifications

Building Blocks Functional Group Carboxylic Acid

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Building Blocks Skeleton Aromatic heterocycle compounds Pyrazine compounds

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Key Words

138775-02-7 sigma138775-02-7 manufacturer138775-02-7 price138775-02-7 structure138775-02-7 SDSbuy 138775-02-7138775-02-7 supplier138775-02-7 uses138775-02-7 molecular weightprice of 138775-02-7138775-02-7 chemical name formula of 138775-02-7

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(2R)-Piperazine-1,2,4-tricarboxylic acid 4-benzyl ester 1-tert-butyl ester

CAS No. 138775-02-7

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