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CS-W001157 4
Total: USD 88.00

tert-Butyl (2-hydroxypropyl)(methyl)carbamate

  • CAS No. 138373-85-0

  • Cat. No. CS-0371503
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

tert-Butyl (2-hydroxypropyl)(methyl)carbamate|CS-0371503

Structure of 138373-85-0

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General Information

  • CAS No. 138373-85-0
  • Cat. No. CS-0371503
  • Purity ≥97%
  • MDL No. None
  • Storage 4°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₁₉NO₃
  • Molecular Weight 189.25
  • Synonym(s) tert-butyl N-(2-hydroxypropyl)-N-methylcarbamate
  • SMILES O=C(OC(C)(C)C)N(CC(O)C)C

Description

tert-Butyl (2-hydroxypropyl)(methyl)carbamate features a hydroxyl-bearing alkyl chain flanked by a tert-butyl carbamate and methyl substituent, enabling selective protection of primary amines in complex synthesis. This bench-stable derivative integrates seamlessly into peptide coupling workflows, offering enhanced solubility and predictable deprotection under mild acidic conditions.

Application

tert-Butyl (2-hydroxypropyl)(methyl)carbamate serves as a bifunctional building block in synthetic chemistry, combining a readily cleavable tert-butyl carbamate protecting group with a secondary alcohol and a methylamino moiety. It enables orthogonal protection strategies in peptide and small-molecule synthesis, facilitating selective transformations under mild conditions. The molecule exhibits good bench stability and simplifies purification due to its solubility profile and predictable deprotection behavior, making it valuable for iterative synthesis workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   49.77
  • LogP   1.2341
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   2

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