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CS-W001157 4
Total: USD 88.00

Methyltetrazine-acid

  • CAS No. 1380500-88-8

  • Cat. No. CS-0115060
  • Purity≥96%
  • MDL No.MFCD28334556

*For research and further manufacturing use only, not for direct human use.

Methyltetrazine-acid|CS-0115060

Structure of 1380500-88-8

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General Information

  • CAS No. 1380500-88-8
  • Cat. No. CS-0115060
  • Purity ≥96%
  • MDL No. MFCD28334556
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₁₀N₄O₂
  • Molecular Weight None
  • Synonym(s) None
  • SMILES O=C(O)CC1=CC=C(C2=NN=C(C)N=N2)C=C1

Description

Methyltetrazine-acid delivers a reactive handle for bioconjugation, combining a methyl-substituted tetrazine ring with a carboxylic acid functionality. This pairing enables efficient inverse electron-demand Diels-Alder reactions with trans-cyclooctene derivatives, while the acid group supports direct coupling to amines or derivatization via standard peptide synthesis protocols. The molecule exhibits enhanced stability under physiological conditions and maintains high reactivity in aqueous environments.

Application

Methyltetrazine-acid serves as a reliable bioorthogonal handle for site-specific conjugation in complex molecular systems. Its acid-functionalized tetrazine moiety enables efficient inverse electron-demand Diels-Alder (IEDDA) reactions with trans-cyclooctene (TCO) derivatives under physiological conditions. The methyl-substituted tetrazine enhances stability and reaction kinetics, while the carboxylic acid group facilitates purification and derivatization via standard amide coupling protocols. This dual-functional architecture supports modular synthesis of antibody-drug conjugates, protein probes, and functionalized polymers with high selectivity and minimal background labeling.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H312-H315-H319-H332-H335
Precautionary Statements : P260-P261-P264-P270-P271-P280-P301+P310-P302+P352-P304+P340-P304+P341-P305+P351+P338-P312-P330-P332+P313-P337+P313-P362+P364-P363-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   88.86
  • LogP   0.86912
  • H_Acceptors   5
  • H_Donors   1
  • Rotatable_Bonds   3

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