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CS-W001157 4
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6-Chloro-2-methylnicotinic acid

  • CAS No. 137129-98-7

  • Cat. No. CS-W006084
  • Purity≥95%
  • MDL No.MFCD09842452

*For research and further manufacturing use only, not for direct human use.

6-Chloro-2-methylnicotinic acid|CS-W006084

Structure of 137129-98-7

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General Information

  • CAS No. 137129-98-7
  • Cat. No. CS-W006084
  • Purity ≥95%
  • MDL No. MFCD09842452
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₆ClNO₂
  • Molecular Weight 171.58
  • Synonym(s) 6-Chloro-2-methylpyridine-3-carboxylic acid
  • SMILES O=C(O)C1=C(C)N=C(Cl)C=C1

Description

6-Chloro-2-methylnicotinic acid features a chlorine substituent at the 6-position and a methyl group at the 2-position of the nicotinic acid scaffold. This electron-deficient heterocycle serves as a key building block in medicinal chemistry, enabling direct incorporation into bioactive molecules through amidation or esterification. The combination of steric and electronic modulation enhances metabolic stability and target engagement in pharmaceutical development workflows.

Application

6-Chloro-2-methylnicotinic acid serves as a versatile building block in medicinal chemistry, enabling the synthesis of bioactive heterocycles and pharmaceutical intermediates. Its ortho-substituted pyridine core provides enhanced reactivity for downstream functionalization, while the chloro and methyl groups offer defined regiochemical control. The compound exhibits good bench stability and facilitates efficient coupling reactions, making it well-suited for scale-up applications in API development.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   50.19
  • LogP   1.74162
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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