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CS-W001157 4
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N,N'-Dimethyl-N,N'-bis(2-pyridylmethyl)ethane-1,2-diamine

  • CAS No. 136768-57-5

  • Cat. No. CS-0110468
  • Purity≥97%
  • MDL No.MFCD29039185

*For research and further manufacturing use only, not for direct human use.

N,N'-Dimethyl-N,N'-bis(2-pyridylmethyl)ethane-1,2-diamine|CS-0110468

Structure of 136768-57-5

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General Information

  • CAS No. 136768-57-5
  • Cat. No. CS-0110468
  • Purity ≥97%
  • MDL No. MFCD29039185
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₆H₂₂N₄
  • Molecular Weight 270.38
  • Synonym(s) None
  • SMILES N=1C=CC=CC1CN(C)CCN(C)CC2=NC=CC=C2

Description

This bidentate ligand features two pyridylmethyl arms tethered to a central ethane-1,2-diamine backbone, enabling robust chelation of transition metals. The dimethyl substitution enhances solubility and steric control, while the pyridyl groups provide strong coordination sites. Ideal for metal complexation in catalytic and supramolecular applications.

Application

N,N'-Dimethyl-N,N'-bis(2-pyridylmethyl)ethane-1,2-diamine serves as a versatile bidentate ligand in transition metal catalysis, enabling efficient coordination to copper(I), palladium(II), and nickel(II) centers. Its pyridyl and amine functionalities provide strong chelation stability, facilitating cross-coupling reactions and C–H functionalization under mild conditions. The dimethyl substitution enhances solubility and steric control, while the ethane-1,2-diamine backbone ensures robust complex formation. This ligand demonstrates excellent bench stability and compatibility with standard synthetic workflows, making it ideal for catalyst development in medicinal chemistry and process-scale applications.

Synthesis

  • Route1
    • In-stock
      2-(Chloromethyl)pyridine hydrochloride|CS-W007502
      6959-47-3
    • null|null
      110-70-3
    • ~81%
    • In-stock
      N,N'-Dimethyl-N,N'-bis(2-pyridylmethyl)ethane-1,2-diamine|CS-0110468
      136768-57-5

    References

    • Pandiyan, Thangarasu; Guadalupe, Hernandez J.; Cruz, Julian; Bernes, Sylvain; Ugalde-Salvdivar, Victor M.; Gonzalez, Ignacio European Journal of Inorganic Chemistry, 2008 , # 21 p. 3274 - 3285
  • Route2
    • null|null
      4377-33-7
    • null|null
      110-70-3
    • ~78%
    • In-stock
      N,N'-Dimethyl-N,N'-bis(2-pyridylmethyl)ethane-1,2-diamine|CS-0110468
      136768-57-5

    References

    • Iturrospe, Amaia; Artetxe, Benat; Reinoso, Santiago; San Felices, Leire; Vitoria, Pablo; Lezama, Luis; Gutierrez-Zorrilla, Juan M. Inorganic Chemistry, 2013 , vol. 52, # 6 p. 3084 - 3093
  • Route3

    References

    • Iturrospe, Amaia; Artetxe, Benat; Reinoso, Santiago; San Felices, Leire; Vitoria, Pablo; Lezama, Luis; Gutierrez-Zorrilla, Juan M. Inorganic Chemistry, 2013 , vol. 52, # 6 p. 3084 - 3093

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   32.26
  • LogP   2.0404
  • H_Acceptors   4
  • H_Donors   0
  • Rotatable_Bonds   7

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